                               SEQUENCE LISTING

<110> SYMIC IP, LLC
 
<120> BIOCONJUGATES WITH CHEMICALLY MODIFIED BACKBONES

<130> 38FE-253694-WO

<140> PCT/US2018/041280
<141> 2018-07-09

<150> 62/530,066
<151> 2017-07-07

<160> 85    

<170> PatentIn version 3.5

<210> 1
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Arg Arg Ala Asn Ala Ala Leu Lys Ala Gly Glu Leu Tyr Lys Ser Ile 
1               5                   10                  15      


Leu Tyr 
        


<210> 2
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Gly Glu Leu Tyr Lys Ser Ile Leu Tyr 
1               5                   


<210> 3
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Arg Arg Ala Asn Ala Ala Leu Lys Ala Gly Glu Leu Tyr Lys Cys Ile 
1               5                   10                  15      


Leu Tyr 
        


<210> 4
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Glu Leu Tyr Lys Cys Ile Leu Tyr 
1               5                   


<210> 5
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Arg Leu Asp Gly Asn Glu Ile Lys Arg 
1               5                   


<210> 6
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Ala His Glu Glu Ile Ser Thr Thr Asn Glu Gly Val Met 
1               5                   10              


<210> 7
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Asn Gly Val Phe Lys Tyr Arg Pro Arg Tyr Phe Leu Tyr Lys His Ala 
1               5                   10                  15      


Tyr Phe Tyr Pro Pro Leu Lys Arg Phe Pro Val Gln 
            20                  25              


<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Cys Gln Asp Ser Glu Thr Arg Thr Phe Tyr 
1               5                   10  


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Thr Lys Lys Thr Leu Arg Thr 
1               5           


<210> 10
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr 
1               5                   10                  15      


Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His Met 
            20                  25              


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Ser Gln Asn Pro Val Gln Pro 
1               5           


<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ser Tyr Ile Arg Ile Ala Asp Thr Asn Ile Thr 
1               5                   10      


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Lys Glu Leu Asn Leu Val Tyr Thr 
1               5               


<210> 14
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Gly Ser Ile Thr 
1               


<210> 15
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val 
1               5                   10          


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Gln Leu Tyr Lys Ser Ile Leu Tyr 
1               5                   


<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gly Gln Leu Tyr Lys Ser Ile Leu Tyr Gly Ser Gly Ser Gly Ser Arg 
1               5                   10                  15      


Arg 
    


<210> 18
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Arg Arg Ala Asn Ala Ala Leu Lys Ala Gly Gln Leu Tyr Lys Ser Ile 
1               5                   10                  15      


Leu Tyr 
        


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Thr Leu Thr Tyr Thr Trp Ser 
1               5           


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Thr Leu Thr Tyr Thr Trp Ser Gly Ser Gly 
1               5                   10  


<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Lys Leu Trp Val Leu Pro Lys 
1               5           


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser 
1               5                   10  


<210> 23
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Alanine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Biphenylalanine

<400> 23
Ala Trp His Cys Thr Thr Lys Phe Pro His His Tyr Cys Leu Tyr Xaa 
1               5                   10                  15      


<210> 24
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Alanine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Biphenylalanine

<400> 24
Ala His Lys Cys Pro Trp His Leu Tyr Thr Thr His Tyr Cys Phe Thr 
1               5                   10                  15      


Xaa 
    


<210> 25
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Alanine

<400> 25
Ala His Lys Cys Pro Trp His Leu Tyr Thr His Tyr Cys Phe Thr 
1               5                   10                  15  


<210> 26
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> 4-Hydroxyproline

<400> 26
Gly Arg Pro Gly Glu Arg 
1               5       


<210> 27
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> 4-Hydroxyproline

<400> 27
Gly Met Pro Gly Glu Arg 
1               5       


<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> 4-Hydroxyproline

<400> 28
Gly Leu Pro Gly Glu Asn 
1               5       


<210> 29
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> 4-Hydroxyproline

<400> 29
Gly Leu Pro Gly Glu Arg 
1               5       


<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Gly Leu Lys Gly Glu Asn 
1               5       


<210> 31
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> 4-Hydroxyproline

<220>
<221> MOD_RES
<222> (12)..(12)
<223> 4-Hydroxyproline

<400> 31
Gly Phe Pro Gly Glu Arg Gly Val Glu Gly Pro Pro Gly Pro Ala 
1               5                   10                  15  


<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
His Val Trp Met Gln Ala Pro Gly Gly Gly Lys 
1               5                   10      


<210> 33
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Trp Tyr Arg Gly Arg Leu 
1               5       


<210> 34
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Trp Thr Cys Ser Gly Asp Glu Tyr Thr Trp His Cys 
1               5                   10          


<210> 35
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Trp Thr Cys Val Gly Asp His Lys Thr Trp Lys Cys 
1               5                   10          


<210> 36
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Gln Trp His Cys Thr Thr Arg Phe Pro His His Tyr Cys Leu Tyr Gly 
1               5                   10                  15      


<210> 37
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Ser Thr Trp Thr Trp Asn Gly Ser Ala Trp Thr Trp Asn Glu Gly Gly 
1               5                   10                  15      


Lys 
    


<210> 38
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Ser Thr Trp Thr Trp Asn Gly Thr Asn Trp Thr Arg Asn Asp Gly Gly 
1               5                   10                  15      


Lys 
    


<210> 39
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Cys Val Trp Leu Trp Glu Gln Cys 
1               5               


<210> 40
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Cys Val Trp Leu Trp Glu Asn Cys 
1               5               


<210> 41
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Cys Met Thr Ser Pro Trp Arg Cys 
1               5               


<210> 42
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Cys Pro Gly Arg Val Met His Gly Leu His Leu Gly Asp Asp Glu Gly 
1               5                   10                  15      


Pro Cys 
        


<210> 43
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Lys Leu Trp Leu Leu Pro Lys 
1               5           


<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Leu Ser Glu Leu Arg Leu His Glu Asn 
1               5                   


<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Leu Thr Glu Leu His Leu Asp Asn Asn 
1               5                   


<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Leu Ser Glu Leu Arg Leu His Asn Asn 
1               5                   


<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Leu Ser Glu Leu Arg Leu His Ala Asn 
1               5                   


<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Leu Arg Glu Leu His Leu Asn Asn Asn 
1               5                   


<210> 49
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Arg Arg Ala Asn Ala Ala Leu Lys Ala Gly Glu Leu Tyr Lys Ser Ile 
1               5                   10                  15      


Leu Tyr Gly Cys 
            20  


<210> 50
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Met Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile 
1               5                   10                  15      


Glu Asn Gly Ala Phe Gln Gly Met Lys Lys 
            20                  25      


<210> 51
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Lys Glu Leu Asn Leu Val Tyr 
1               5           


<210> 52
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Asp Ala Arg Lys Ser Glu Val Gln Lys 
1               5                   


<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
His Val Trp Met Gln Ala Pro 
1               5           


<210> 54
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
His Trp Gly Ser Leu Arg Ala 
1               5           


<210> 55
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Biphenylalanine

<400> 55
Gly Lys Trp His Cys Thr Thr Lys Phe Pro His His Tyr Cys Leu Tyr 
1               5                   10                  15      


Xaa 
    


<210> 56
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Arg Val Met His Gly Leu His Leu Gly Asp Asp Glu 
1               5                   10          


<210> 57
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(12)
<223> D-amino acid

<400> 57
Glu Asp Asp Gly Leu His Leu Gly His Met Val Arg 
1               5                   10          


<210> 58
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Arg Val Met His Gly Leu His Leu Gly Asn Asn Gln 
1               5                   10          


<210> 59
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(12)
<223> D-amino acid

<400> 59
Gln Asn Asn Gly Leu His Leu Gly His Met Val Arg 
1               5                   10          


<210> 60
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Gly Gln Leu Tyr Lys Ser Ile Leu Tyr Gly Ser Gly 
1               5                   10          


<210> 61
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Gly Ser Gly Gln Leu Tyr Lys Ser Ile Leu Tyr 
1               5                   10      


<210> 62
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Gly Ser Gly Gly Gln Leu Tyr Lys Ser Ile Leu Tyr 
1               5                   10          


<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Lys Gln Leu Asn Leu Val Tyr Thr 
1               5               


<210> 64
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Cys Val Trp Leu Trp Gln Gln Cys 
1               5               


<210> 65
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Trp Arg Glu Pro Ser Phe Ser Ala Leu Ser 
1               5                   10  


<210> 66
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg 
1               5                   10                  15      


Pro Ala Pro Pro Pro Ile Ser Gly Gly Gly Tyr Arg 
            20                  25              


<210> 67
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Gly His Arg Pro Leu Asn Lys Lys Arg Gln Gln Ala Pro Ser Leu Arg 
1               5                   10                  15      


Pro Ala Pro Pro Pro Ile Ser Gly Gly Gly Tyr Arg 
            20                  25              


<210> 68
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Ser Ile Leu Tyr 
1               


<210> 69
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Arg Arg Ala Asn Ala Ala Leu Lys Ala Gly Glu Leu Tyr Lys Ser Ile 
1               5                   10                  15      


Leu Tyr Gly Ser Gly 
            20      


<210> 70
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Gly Gly Gly Gly 
1               


<210> 71
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Gly Gly Gly Gly Gly 
1               5   


<210> 72
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Gly Ser Gly Cys 
1               


<210> 73
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Gly Ser Gly Ser Gly 
1               5   


<210> 74
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Gly Ser Gly Ser Gly Ser 
1               5       


<210> 75
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Gly Ser Gly Arg Arg 
1               5   


<210> 76
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Gly Ser Gly Ser Arg Arg 
1               5       


<210> 77
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 77
Gly Ser Gly Ser Gly Arg Arg 
1               5           


<210> 78
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 78
Gly Ser Gly Ser Gly Ser Arg Arg 
1               5               


<210> 79
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> This region may encompass 0-5 residues 

<400> 79
Lys Lys Lys Lys Lys Gly Ser Gly 
1               5               


<210> 80
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Lys Gly Ser Gly 
1               


<210> 81
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Gly Ser Gly Lys Arg Arg Gly Ser Gly 
1               5                   


<210> 82
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Lys Lys Gly Ser Gly 
1               5   


<210> 83
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Lys Lys Lys Gly Ser Gly 
1               5       


<210> 84
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Gly Glu Leu Tyr Lys Ser Ile Leu Tyr Gly Ser Gly 
1               5                   10          


<210> 85
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Lys Arg Arg Gly Ser Gly 
1               5       


